Eagle

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Note: Upload the target antigen PDB file, one or more valid chain identifiers and either select to calculate epitope directly from a known binder in the PDB or upload an epitope file.
Note: In addition, you can also choose to generate only CDR3 or only CDRs based on a given frame. If any of these options are chosen, you will be required to provide the sequence for the frame as a fasta file.

Input options

Antigen file upload Accepted format: .pdb

Antigen chain id(s) Specify one or more chain identifiers

Design type Choose a type of design

Email address

Number of predictions (1-1000)

Calculate epitope from pdb file

Get epitope from an epitope file

Citation: If you use Eagle, please cite: Cohen T., Schneidman-Duhovny D. (2023) Epitope-specific antibody design using diffusion models on the latent space of ESM embeddings NeurIPS 2023 Generative AI and Biology (GenBio) Workshop

Contact: tomer.cohen13@mail.huji.ac.il

Acknowledgement: We are grateful for the support of the Center for Interdisciplinary Data Science Research (CIDR) at the Hebrew University of Jerusalem. In particular, we would like to thank Haimasree Bhattacharya from CIDR for her contributions